The global air quality challenge covers a broad variety of scales in spatial and temporal terms as well as in the context of actors involved. Addressing these dimensions calls for a broad, participatory, dynamic, and demand-oriented approach that can rely on a multidisciplinary expert and user community. In addressing the global air pollution challenge, UNEP through GEMS/AIR has developed a strategy to guide the operations and work plan development. This strategy proposes an agile approach to catalyze transformative change in the operational framework of GEMS/Air. It applies an innovative approach to formulating a revitalized GEMS/Air Program.